Understanding Sickle Cell Disease: A Closer Look

September is National Sickle Cell Awareness Month. Did you know that around 100,000 people in the United States are affected by this condition?

Sickle Cell Disease (SCD) is a group of inherited disorders that affect the red blood cells, the essential carriers of oxygen throughout our bodies. Normally, red blood cells, also known as erythrocytes, are round and flexible, allowing them to flow smoothly through blood vessels. Their ability to carry oxygen is due to hemoglobin, a protein found within these cells.

In individuals with sickle cell disease, hemoglobin is abnormal, causing the red blood cells to take on a rigid, sickle shape. These sickle-shaped cells not only die prematurely—leading to a constant shortage of healthy red blood cells—but they can also become stuck in blood vessels, resulting in an obstruction of blood flow. This blockage can result in painful episodes known as pain crises, as well as other serious complications.

The impact of sickle cell disease can vary widely among individuals, with symptoms ranging from mild to severe. Unfortunately, the average life expectancy for those living with SCD is more than 20 years shorter than the national average in the United States. Sickle cell disease can affect various parts of the body, including the brain, eyes, liver, and heart, highlighting the importance of awareness and education about this condition. By understanding sickle cell disease better, we can advocate for those affected and support initiatives aimed at improving care and outcomes.

To learn more about Sickle Cell Disease and current treatments, take the accredited continuing education activity The Pharmacological Landscape of Sickle Cell Disease available at https://www.akhcme.com/courses/240222/.

Resources:
1. Centers for Disease Control and Prevention. About sickle cell disease. Centers for Disease Control and Prevention. https://www.cdc.gov/sickle-cell/about/index.html